Nucleic Acids

Thermodynamics of Nucleic Acids

Double stranded DNA's nucleic acid structure can be impacted by temperature (dsDNA). The temperature at which half of the DNA strands are in random coil or single stranded (ssDNA) form is known as the melting temperature. Tm is influenced by the nucleotide sequence and size of the DNA molecule. Thus, the two strands of DNA are in a state of dissociation the DNA molecule is molten