Nucleic Acids

Peptide Nucleic Acid as Therapeutic Agent

With a repeating N-(2-aminoethyl)-glycine peptide backbone coupled to purine and pyrimidine nucleobases via a linker, PNA are synthetic analogues of DNA. PNA-based technology has received a lot of interest as a viable method for gene modification due to the unique qualities of PNA, including resistance to enzymatic digestion, increased bio stability, and excellent hybridization affinity toward DNA and RNA. However, inadequate intracellular absorption presents a significant obstacle to the use of PNA. To improve PNA delivery and ensure that it reaches the appropriate spot, some solutions have been devised