Peptide nucleic acid as therapeutic agent


 PNA are synthetic analog of DNA with a repeating N-(2-aminoethyl)-glycine peptide backbone connected to purine and pyrimidine nucleobases via a linker. The unique properties of PNA, including resistance to enzymatic digestion, higher bio stability combined with great hybridization affinity toward DNA and RNA, it has attracted great attention toward PNA- based technology as a promising approach for gene alteration. However, an important challenge in utilizing PNA is poor intracellular uptake. Some strategies have been developed to enhance the delivery of PNA in order to reach cognate site.



 



 


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